Josselyn, S. A. & Tonegawa, S. Reminiscence engrams: recalling the previous and imagining the longer term. Science 367, eaaw4325 (2020).
Liu, X. et al. Optogenetic stimulation of a hippocampal engram prompts worry reminiscence recall. Nature 484, 381–385 (2012).
Ramirez, S. et al. Making a false reminiscence within the hippocampus. Science 341, 387–391 (2013).
Roy, D. S. et al. Mind-wide mapping reveals that engrams for a single reminiscence are distributed throughout a number of mind areas. Nat. Commun. 13, 1799 (2022).
Han, J.-H. et al. Selective erasure of a worry reminiscence. Science 323, 1492–1496 (2009).
Dallérac, G., Zapata, J. & Rouach, N. Versatile management of synaptic circuits by astrocytes: the place, when and the way? Nat. Rev. Neurosci. 19, 729–743 (2018).
Kofuji, P. & Araque, A. Astrocytes and conduct. Annu. Rev. Neurosci. 44, 49–67 (2021).
Allen, N. J. & Eroglu, C. Cell biology of astrocyte–synapse interactions. Neuron 96, 697–708 (2017).
Nagai, J. et al. Behaviorally consequential astrocytic regulation of neural circuits. Neuron 109, 576–596 (2021).
Soto, J. S. et al. Astrocyte–neuron subproteomes and obsessive–compulsive dysfunction mechanisms. Nature 616, 764–773 (2023).
Sardar, D. et al. Induction of astrocytic Slc22a3 regulates sensory processing by way of histone serotonylation. Science 380, eade0027 (2023).
Cheng, Y.-T. et al. Social deprivation induces astrocytic TRPA1–GABA suppression of hippocampal circuits. Neuron 111, 1301–1315 (2023).
Lawal, O., Ulloa Severino, F. P. & Eroglu, C. The position of astrocyte structural plasticity in regulating neural circuit perform and conduct. Glia 70, 1467–1483 (2022).
Fleischmann, A. et al. Impaired long-term reminiscence and NR2A-type NMDA receptor-dependent synaptic plasticity in mice missing c-Fos within the CNS. J. Neurosci. 23, 9116–9122 (2003).
Katche, C. et al. Delayed wave of c-Fos expression within the dorsal hippocampus concerned particularly in persistence of long-term reminiscence storage. Proc. Natl Acad. Sci. USA 107, 349–354 (2010).
Lacagnina, A. F. et al. Distinct hippocampal engrams management extinction and relapse of worry reminiscence. Nat. Neurosci. 22, 753–761 (2019).
Khakh, B. S. & Sofroniew, M. V. Range of astrocyte features and phenotypes in neural circuits. Nat. Neurosci. 18, 942–952 (2015).
Papouin, T., Dunphy, J., Tolman, M., Foley, J. C. & Haydon, P. G. Astrocytic management of synaptic perform. Philos. Trans. R. Soc. Lond. B Biol. Sci. 372, 20160154 (2017).
Endo, F. et al. Molecular foundation of astrocyte range and morphology throughout the CNS in well being and illness. Science 378, eadc9020 (2022).
Kol, A. et al. Astrocytes contribute to distant reminiscence formation by modulating hippocampal–cortical communication throughout studying. Nat. Neurosci. 23, 1229–1239 (2020).
Cheng, Y.-T. et al. Inhibitory enter directs astrocyte morphogenesis by way of glial GABABR. Nature 617, 369–376 (2023).
Henneberger, C., Papouin, T., Oliet, S. H. R. & Rusakov, D. A. Lengthy-term potentiation is dependent upon launch of d-serine from astrocytes. Nature 463, 232–236 (2010).
Huang, A. Y.-S. et al. Area-specific transcriptional management of astrocyte perform oversees native circuit actions. Neuron 106, 992–1008 (2020).
Adamsky, A. et al. Astrocytic activation generates de novo neuronal potentiation and reminiscence enhancement. Cell 174, 59–71 (2018).
Suthard, R. L. et al. Basolateral amygdala astrocytes are engaged by the acquisition and expression of a contextual worry reminiscence. J. Neurosci. https://doi.org/10.1523/JNEUROSCI.1775-22.2023 (2023).
Yap, E.-L. & Greenberg, M. E. Exercise-regulated transcription: bridging the hole between neural exercise and conduct. Neuron 100, 330–348 (2018).
Gleichman, A. J., Kawaguchi, R., Sofroniew, M. V. & Carmichael, S. T. A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors utilizing microRNA focusing on sequences. Nat. Commun. 14, 7426 (2023).
Solar, W. et al. Spatial transcriptomics reveal neuron–astrocyte synergy in long-term reminiscence. Nature https://doi.org/10.1038/s41586-023-07011-6 (2024).
Chen, M. B., Jiang, X., Quake, S. R. & Südhof, T. C. Persistent transcriptional programmes are related to distant reminiscence. Nature 587, 437–442 (2020).
Yu, X. et al. Lowering astrocyte calcium signaling in vivo alters striatal microcircuits and causes repetitive conduct. Neuron 99, 1170–1187 (2018).
Ung, Ok., Tepe, B., Pekarek, B., Arenkiel, B. R. & Deneen, B. Parallel astrocyte calcium signaling modulates olfactory bulb responses. J. Neurosci. Res. 98, 1605–1618 (2020).
Choi, J.-H. et al. Interregional synaptic maps amongst engram cells underlie reminiscence formation. Science 360, 430–435 (2018).
Park, H. et al. Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Mol. Mind 8, 7 (2015).
Yu, X. et al. Context-specific striatal astrocyte molecular responses are phenotypically exploitable. Neuron https://doi.org/10.1016/j.neuron.2020.09.021 (2020).
Lin, C.-C. J. et al. Identification of various astrocyte populations and their malignant analogs. Nat. Neurosci. 20, 396–405 (2017).
Morel, L. et al. Molecular and practical properties of regional astrocytes within the grownup mind. J. Neurosci. 37, 8706–8717 (2017).
de Ceglia, R. et al. Specialised astrocytes mediate glutamatergic gliotransmission within the CNS. Nature https://doi.org/10.1038/s41586-023-06502-w (2023).
Ghandour, Ok. et al. Orchestrated ensemble actions represent a hippocampal reminiscence engram. Nat. Commun. 10, 2637 (2019).
Ung, Ok. et al. Olfactory bulb astrocytes mediate sensory circuit processing by way of Sox9 within the mouse mind. Nat. Commun. 12, 5230 (2021).
Rao-Ruiz, P. et al. Engram-specific transcriptome profiling of contextual reminiscence consolidation. Nat. Commun. 10, 2232 (2019).
Lozzi, B., Huang, T.-W., Sardar, D., Huang, A. Y.-S. & Deneen, B. Regionally distinct astrocytes show distinctive transcription issue profiles within the grownup mind. Entrance. Neurosci. https://doi.org/10.3389/fnins.2020.00061 (2020).
Cheng, Y.-T., Woo, J. & Deneen, B. Sculpting astrocyte range by way of circuits and transcription. Neuroscientist https://doi.org/10.1177/10738584221082620 (2022).
Scavuzzo, M. A. et al. Pancreatic cell destiny willpower depends on Notch ligand trafficking by NFIA. Cell Rep. 25, 3811–3827 (2018).
Srinivasan, R. et al. Ca2+ signaling in astrocytes from Ip3r2−/− mice in mind slices and through startle responses in vivo. Nat. Neurosci. 18, 708–717 (2015).
Ewels, P., Magnusson, M., Lundin, S. & Käller, M. MultiQC: summarize evaluation outcomes for a number of instruments and samples in a single report. Bioinformatics 32, 3047–3048 (2016).
Dobin, A. et al. STAR: ultrafast common RNA-seq aligner. Bioinformatics 29, 15–21 (2013).
