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HomenatureMobile ATP demand creates metabolically distinct subpopulations of mitochondria

Mobile ATP demand creates metabolically distinct subpopulations of mitochondria


  • Spinelli, J. B. & Haigis, M. C. The multifaceted contributions of mitochondria to mobile metabolism. Nat. Cell Biol. 20, 745–754 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Quintana-Cabrera, R. & Scorrano, L. Determinants and outcomes of mitochondrial dynamics. Mol. Cell 83, 857–876 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Schworer, S. et al. Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress. EMBO J. 39, e103334 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Arnold, P. Ok. et al. A non-canonical tricarboxylic acid cycle underlies mobile identification. Nature 603, 477–481 (2022).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Linder, S. J. et al. Inhibition of the proline metabolism rate-limiting enzyme P5CS permits proliferation of glutamine-restricted most cancers cells. Nat. Metab. 5, 2131–2147 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhu, J. et al. Mitochondrial NADP(H) era is crucial for proline biosynthesis. Science 372, 968–972 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pilley, S. E. et al. Lack of attachment promotes proline accumulation and excretion in most cancers cells. Sci. Adv. 9, eadh2023 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lee, M. S. et al. Ornithine aminotransferase helps polyamine synthesis in pancreatic most cancers. Nature 616, 339–347 (2023).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gohil, V. M. et al. Nutrient-sensitized screening for medication that shift vitality metabolism from mitochondrial respiration to glycolysis. Nat. Biotechnol. 28, 249–255 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cai, X. et al. Lactate prompts the mitochondrial electron transport chain independently of its metabolism. Mol. Cell 83, 3904–3920 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Titov, D. V. et al. Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio. Science 352, 231–235 (2016).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang, Z. et al. Pyrroline-5-carboxylate synthase senses mobile stress and modulates metabolism by regulating mitochondrial respiration. Cell Demise Differ. 28, 303–319 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang, B. et al. The proline synthesis enzyme P5CS types cytoophidia in Drosophila. J. Genet. Genomics 47, 131–143 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhong, J. et al. Structural foundation of dynamic P5CS filaments. eLife 11, e76107 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen, W. W., Freinkman, E., Wang, T., Birsoy, Ok. & Sabatini, D. M. Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism. Cell 166, 1324–1337 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Edwards-Hicks, J. et al. MYC sensitises cells to apoptosis by driving energetic demand. Nat. Commun. 13, 4674 (2022).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fischer-Zirnsak, B. et al. Recurrent de novo mutations affecting residue Arg138 of pyrroline-5-carboxylate synthase trigger a progeroid type of autosomal-dominant cutis laxa. Am. J. Hum. Genet. 97, 483–492 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kamphorst, J. J. et al. Human pancreatic most cancers tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Most cancers Res. 75, 544–553 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bartman, C. R. et al. Gradual TCA flux and ATP manufacturing in main stable tumours however not metastases. Nature 614, 349–357 (2023).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Collins, T. J., Berridge, M. J., Lipp, P. & Bootman, M. D. Mitochondria are morphologically and functionally heterogeneous inside cells. EMBO J. 21, 1616–1627 (2002).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Benador, I. Y. et al. Mitochondria sure to lipid droplets have distinctive bioenergetics, composition, and dynamics that assist lipid droplet growth. Cell Metab. 27, 869–885 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Han, M. et al. Spatial mapping of mitochondrial networks and bioenergetics in lung most cancers. Nature 615, 712–719 (2023).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Carraro, M. et al. The distinctive cysteine of F-ATP synthase OSCP subunit participates in modulation of the permeability transition pore. Cell Rep. 32, 108095 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Branon, T. C. et al. Environment friendly proximity labeling in residing cells and organisms with TurboID. Nat. Biotechnol. 36, 880–887 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Luengo, A. et al. Elevated demand for NAD+ relative to ATP drives cardio glycolysis. Mol. Cell 81, 691–707 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Stephan, T. et al. MICOS meeting controls mitochondrial internal membrane reworking and crista junction redistribution to mediate cristae formation. EMBO J. 39, e104105 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Quintana-Cabrera, R. et al. The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial perform. Nat. Commun. 9, 3399 (2018).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cogliati, S. et al. Mitochondrial cristae form determines respiratory chain supercomplexes meeting and respiratory effectivity. Cell 155, 160–171 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Detmer, S. A. & Chan, D. C. Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects brought on by CMT2A illness mutations. J. Cell Biol. 176, 405–414 (2007).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Giacomello, M., Pyakurel, A., Glytsou, C. & Scorrano, L. The cell biology of mitochondrial membrane dynamics. Nat. Rev. Mol. Cell Biol. 21, 204–224 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yao, C.-H. et al. Mitochondrial fusion helps elevated oxidative phosphorylation throughout cell proliferation. eLife 8, e41351 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yasuda, T., Ishihara, T., Ichimura, A. & Ishihara, N. Mitochondrial dynamics outline muscle fiber kind by modulating mobile metabolic pathways. Cell Rep. 42, 112434 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hsu, Ok.-S. et al. Most cancers cell survival is determined by collagen uptake into tumor-associated stroma. Nat. Commun. 13, 7078 (2022).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kleele, T. et al. Distinct fission signatures predict mitochondrial degradation or biogenesis. Nature 593, 435–439 (2021).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Rath, S. et al. MitoCarta3.0: an up to date mitochondrial proteome now with sub-organelle localization and pathway annotations. Nucleic Acids Res. 49, D1541–D1547 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wei, M. C. et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and loss of life. Science 292, 727–730 (2001).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Osellame, L. D. et al. Cooperative and impartial roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission. J. Cell Sci. 129, 2170–2181 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Korobova, F., Gauvin, T. J. & Higgs, H. N. A job for myosin II in mammalian mitochondrial fission. Curr. Biol. 24, 409–414 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Adams, Ok. J. et al. Skyline for small molecules: a unifying software program package deal for quantitative metabolomics. J. Proteome Res. 19, 1447–1458 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Heinrich, P. et al. Correcting for pure isotope abundance and tracer impurity in MS-, MS/MS- and high-resolution-multiple-tracer-data from steady isotope labeling experiments with IsoCorrectoR. Sci. Rep. 8, 17910 (2018).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen, W. W., Freinkman, E. & Sabatini, D. M. Speedy immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites. Nat. Protoc. 12, 2215–2231 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cho, Ok. F. et al. Proximity labeling in mammalian cells with TurboID and split-TurboID. Nat. Protoc. 15, 3971–3999 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Vander Heiden, M. G., Chandel, N. S., Williamson, E. Ok., Schumacker, P. T. & Thompson, C. B. Bcl-xL regulates the membrane potential and quantity homeostasis of mitochondria. Cell 91, 627–637 (1997).

    Article 

    Google Scholar
     

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